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pentobarbital will reduce the level or result of lefamulin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Steer clear of coadministration of lefamulin with sturdy or reasonable CYP3A inducers Except the profit outweighs pitfalls. Keep an eye on for minimized efficacy.pentobarbital decreases levels